blood test is an important indicator for comprehensive diagnosis of almost all diseases.In a number of serious pathologies of the organism in the blood levels of gamma-glutamyl (GGT), which is confirmed by the analysis.Which leads to an increase in GGT in the blood?
General information about the "level of GGT" blood
GGT - an enzyme called gamma-glutamyl participating in the metabolism of amino acids in the body.It serves as a catalyst in the implementation of the transfer of gamma glutamyl residue of the same peptide (gamma-glutamyl) to another peptide or an amino acid.GGT predominantly accumulates in the kidney, pancreas and liver.
newborn child up to the age of six months the level of this enzyme may exceed the value of GGT adult.Depending on gender, level of gamma-glutamyl also different.Women and adolescent girls the value of 1 / 3-1 / 4 of the lower than that of men.
Indications for delivery of this analysis are:
- diagnosis of liver pathologies;
- kidney disease;
- control of the course of treatment for prostate cancer, pancreatic cancer;
- suspicion of radiation injury of the liver;
- in assessing the liver toxicity of drugs;
- screening alcoholism.
blood test for GGT rented an empty stomach.Permitted use of small amounts of water.Do not take the medication.One day before the delivery of the analysis should give up fatty, fried foods and alcohol.Not allowed and exercise.In addition, you can not donate blood for research GGT after X-rays, ultrasound and other similar procedures, or the results will not be accurate.
From what increases the level of GGT in the blood?
normal GGT level considered 10.4-33.8 U / L (8-61 IU / l) in men and 8.8-22.0 IU / L (6-36 IU / L) - for women, according to the uses of a method andappropriate laboratory equipment, as well as established standards.If the numbers are different from the fixed indicators, this is indicative of disease - the presence of a particular disease.
great importance to determine the causes of the increase of GGT in the blood is competent transcript analysis.If the numbers increased significantly, it should be re-make the biochemical blood test to confirm the previous one.Decoding analysis should only be a specialist in order to properly determine the cause of the increased value.
believed that 5 of the processes occurring in the body can affect the increased activity of GGT.These include:
- alcohol intoxication;
- tumor growth;
- drug intoxication;
main reasons for increasing the level of GGT in the blood may be the presence of the following diseases:
- cirrhosis or liver cancer;
- stagnant or hemolytic jaundice;
- acute hepatitis;
- kidney disease;
- infectious mononucleosis;
- diabetes, pancreatitis;
- pancreatic cancer or prostate cancer;
Raising this enzyme also occurs after kidney transplantation, with hyperthyroid, after taking certain medications.Indicators GGT never increase in myocardial infarction and bone disease.
Liver and blood level GGT
Although the highest activity of gamma-glutamyl transpeptidase in the kidney, the increase in the serum indices GGT observed primarily in the hepatobiliary system (marker of cholestasis).
enzyme GGT level increased at any liver disease.This figure is especially high in cases of hepatic occlusion figures may exceed the permissible levels of 5 to 30 times.High levels of the enzyme is fixed in the case of neoplastic diseases of the liver, especially in the diagnosis of primary tumor and metastases in the liver.
greater sensitivity compared to other analyzes different levels of GGT levels in the diagnosis of cholecystitis, obstructive jaundice and cholangitis.
Excess rates from 2 to 5 times (moderate change) may indicate:
- infectious hepatitis;
- fatty liver;
- drug intoxication;
- diabetic ketoacidosis.
patients with a diagnosis of "pancreatitis", "alcoholic cirrhosis", as well as suffering from a malignant disease of the pancreas enzyme GGT performance may increase by 5 to 15 times.
particularly important to conduct this analysis with long-term alcohol abuse.In such patients, the level of blood GGPT may depend on the amount of alcohol taken, so the test may be used in controlling the treatment of alcoholism.If terminated to consume alcoholic beverages, the enzyme activity in the blood can be reduced over 10% up to 50 days.